I'm sure it probably did feel very unpleasant, possibly to the point he believed it to be true. However, that doesn't mean it is true. It doesn't necessarily mean he was lying, only that he could be wrong.

[He makes an unpleasant noise at the mention of Jonathan. Of course that piker had something to do with things being complicated now. He seemed to have a weakness for destructive maniacs.]

It sounds rather like an addiction. Do you think the serum you designed could have a positive effect on it?

I'm not sure I understand how or why this time it is different. What evidence does he have to back this up?